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The 4-decades long effort to create an AIDS vaccine suffered a blow with news that a vaccine in a late stage trial was discontinued because results showed it to be ineffective. What are the obstacles?

Large chains like Panera and P.F. Chang's as well as neighborhood hangouts are increasingly experimenting with the subscription model as a way to ensure steady revenue and customer visits.

Neither candidate was above the 50% threshold needed to win outright under Georgia law. This sets up a post-Thanksgiving showdown in what is already the country's most expensive Senate race.

The 31-year-old Los Angeles Dodgers star got an unprecedented two-season suspension without pay for violating the league's domestic violence and sexual assault policy. He can resume play this spring.

Listen to a playlist of the songs NPR stations played over and over and over in 2022.

The world's No.2 economy grew by 3% in 2022, less than half of the previous year's rate, official data showed Tuesday as China faced pressure from anti-virus controls and a real estate slump.

President Biden is using his budget to show how he could cut the deficit and still fund his pledges like universal preschool, paid leave and more childcare funding.

Trump-aligned voters are rallying around the former president in the wake of his indictment. Trump remains the frontrunner for the 2024 Republican nomination.

$575 million increase gives Pritzker leeway in budget talks as fears of recession persist

The historic indictment of the former president raises all sorts of legal, political and logistical questions. While it's early days, experts expect a delayed trial after Tuesday's arraignment.