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Three decades ago, Congress set up a system to encourage drug companies to develop treatments for rare diseases. The law has worked, but at a high cost.

The Tea Party and other conservatives argue that Mitt Romney lost the election because he was "too moderate." And they are calling for a complete overhaul of the Republican Party. But the evolving demographics may have played a bigger role.

Winter nights in Ulaanbaatar can drop to minus 20 degrees Fahrenheit. Many residents without electricity burn coal to heat their homes, leading to toxic air and health problems.

Watch 25 of the year's greatest, most surprising Tiny Desk performances, featuring just a sampling of the gifted artists who passed through NPR Music's office this year.

Some of the candidates participated in one debate in Chicago while the others squared off in another.

The Los Angeles County Medical Examiner said that it has received notification of 10 fire-related deaths as firefighters battle multiple blazes for a third consecutive night.

Hints are popping up that the controversial rideshare service called Uber may be expanding its reach in Illinois. Uber is riding a wave of victory in...

Three major media groups said they would lend staff and equipment to ensure the satirical magazine can continue publication after a deadly attack on its offices in Paris.

A northern Illinois social services group is again facing the likelihood of closure -- at least temporarily -- as the result of the Illinois budget…

It was a Norman Rockwell moment – Americana: A father and son playing catch.I was young. I had shoved my left hand into a birthday present — a new…