Pancreatic cancer is among the most deadly forms of cancer, and it can be difficult to catch early. But there’s some good news: Clinical trials of a new drug called daraxonrasib found that it doubled the survival time of patients with advanced pancreatic cancer. And some oncologists are calling it a game changer—not just for pancreatic cancer, but potentially other forms of cancer too. Ira talks with oncologist Zev Wainberg, who led a clinical trial for the drug. Plus, ALS is a degenerative disease that causes patients to lose their ability to walk, swallow and eventually to breathe. Now, there’s a drug for a rare genetic form of ALS that can slow the progression or even reverse some of these symptoms. Ira talks with New York Times health and science reporter Pam Belluck about this new treatment. Guests: Dr. Zev Wainberg is a co-director of UCLA Health’s GI Oncology Program. Pam Belluck is a health and science reporter for The New York Times. Other episodes you may enjoy: mRNA Vaccine For Pancreatic Cancer Continues To Show Promise How do clinical trials work, and who can participate? Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

On a hot summer day, there’s nothing better than a dip in a cold pool. But you know who can ruin that for you? A scientist who studies pool chemistry. What chemical reactions are happening in that swimming pool when the water comes into contact with our bodily fluids and skin products? Environmental engineer Ernest Blatchley sits down with Flora Lichtman to discuss his findings after two decades of research, including how urine in a pool makes that chlorine smell, and his work to make the air of the Paris Olympics’ indoor pools less toxic. Guest: Dr. Ernest Blatchley is a professor of environmental engineering at Purdue University, based in West Lafayette, Indiana. Other episodes you may enjoy: A ‘Dune’-Inspired Space Suit To Turn Astronaut Pee Into Water The Evolution Of An Enzyme Engineer Who Changed Chemistry Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The federal Office of Management and Budget (OMB) has proposed rule changes that would bring a major shift in how scientific grants are awarded by U.S. government agencies. Under the current process, researchers submit grant proposals that are then vetted and scored by a committee of experts in that scientific field, with top-scoring proposals recommended for funding. If its proposed changes are enacted, the OMB would insert a political review into the process, allowing administration officials to determine whether grant proposals are aligned with administration priorities, regardless of their scientific merit. Those proposed rules are now in a public comment period. Holden Thorp, editor in chief of the Science family of journals, joins Ira to explain why he called the change “another red alert for American science” in a recent editorial. Guest: Dr. Holden Thorp is editor in chief of the Science family of journals, at the American Association for the Advancement of Science. Other episodes you may enjoy: A Science Historian Tackles Ghostwriting In Scientific PapersWhat Do mRNA Funding Cuts Mean For Future US Research? Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

If you have arachnophobia, consider this your opportunity to try exposure therapy: A new study suggests that 415 million years ago, in modern-day England and Wales, a scorpion the length of a golden retriever was scurrying around, complete with 6-inch pincers. Flora talks with lead study author Richie Howard about the finding. If you’re grossed out by a 3-foot scorpion, you’re not alone. But, scorpion researcher Lauren Esposito says we’ve got it all wrong—scorpions are wonderful and caring creatures. Guests: Dr. Richie Howard is an invertebrate paleontologist and curator of fossil arthropods at the Natural History Museum in London, England. Dr. Lauren Esposito is a scorpion researcher and director of the non-profit Islands and Seas and founder of 500 Queer Scientists. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The FDA recently approved a sunscreen ingredient called bemotrizinol, or BEMT, that’s been used in Europe and Asia for years. This is the first new sunscreen ingredient approved in the United States in over two decades. Meanwhile, skin cancer has become the most common cancer in the U.S. Flora discusses the chemistry of sunblock with a sunscreen chemist AJ Addae, and the regulatory process that led to this approval with health journalist Michael Scaturro. Guests: Michael Scaturro is a health journalist based in New York City. AJ Addae is a chemistry PhD student at UCLA and founder of SULA Labs. Other episodes you may enjoy: Understanding Sunscreen Ingredients And Which Ones You Need Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.